Researchers in the Tzahor Lab investigate how the immune system can be harnessed to regenerate damaged heart tissue, focusing on the emerging field of cardioimmunology. They study how immune cells such as macrophages, neutrophils, and T cells influence healing after cardiac injury—either enabling regeneration or driving fibrosis—and draw inspiration from the neonatal heart’s short-lived ability to fully recover after damage. To uncover and reactivate these regenerative programs, the team uses high‑resolution molecular tools like single‑cell profiling, spatial transcriptomics, and in vivo injury models, and they also test repurposed immunomodulatory drugs such as Copaxone to shift the post‑injury immune environment toward repair.
